Summary


Microscopy of worms taken from animals treated with tetracycline for 14 and 21 days (14 d and 21 d) demonstrated substantial morphologic effects on the Wolbachia endobacterium by 14 d and complete degeneration of the endobacterial structures by 21 d. 3
[[SCORE=1.0]] [[WRD_COUNT = 84]]
We observed upregulation of transcripts primarily encoding proteins involved in amino acid synthesis and protein translation, and downregulation of transcripts involved in cuticle biosynthesis after both 7 d and 14 d of treatment. 3
[[SCORE=0.729166666667]] [[WRD_COUNT = 69]]


References


@article{3,
author = {Ghedin E, Hailemariam T, Depasse JV, Zhang X, 
Oksov Y, Unnasch TR, Lustigman S },
title = {Brugia malayi Gene Expression in Response to the 
Targeting of the Wolbachia Endosymbiont by Tetracycline 
Treatment. },
journal = {PLoS neglected tropical diseases },
year = {}
}